When drug trials go terribly wrong

Christopher Lane of Northwestern University, the author of Shyness: How Normal Behavior Became a Sickness, blogs for Psychology Today about the death of Dan Markingson in a University of Minnesota drug trial.

Dr. Whistleblower

"Dr. Romney C. Andersen, a Walter Reed Army Medical Center surgeon, was surprised last summer when his neighbor, a fellow doctor, congratulated him on a new medical journal study bearing his name.

What study?” Dr. Andersen asked. Soon, he was not the only person asking questions. Army officials, alerted by Dr. Andersen, began an investigation. They uncovered an apparent case of falsified research by a doctor who had befriended Dr. Andersen when they both worked at Walter Reed, treating American soldiers severely injured in Iraq."

Read more in the New York Times.

Give Blood Pressure Drugs to All

Blood-pressure-lowering drugs should be offered to everyone, regardless of their blood pressure level, as a safeguard against coronary heart disease and stroke, researchers who conducted a meta-analysis of 147 randomized trials (comprising 958,000 people) conclude in the May 19 issue of BMJ.

“Guidelines on the use of blood-pressure-lowering drugs can be simplified so that drugs are offered to people with all levels of blood pressure,” write Drs Malcolm R Law and Nicholas Wald (Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, UK). “Our results indicate the importance of lowering blood pressure in everyone over a certain age, rather than measuring it in everyone and treating it in some.”

“Whatever your blood pressure, you benefit from lowering it further,” Law told heartwire . “Everyone benefits from taking blood-pressure-lowering drugs. There is no one who does not benefit because their blood pressure is so-called normal.”

Six years ago, Law and Wald advocated the use of a polypill--containing a statin, three blood-pressure-lowering drugs (each at half the standard dose), folic acid, and aspirin--which they maintained could prevent heart attacks and stroke if taken by everyone 55 years and older and by everyone with existing cardiovascular disease.

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Opening up the FDA?

The FDA may see some changes soon, says the New York Times. "The goal is to open up a system in which the agency failed to inform the public that a widely prescribed heartburn drug was especially toxic to babies; that a diabetes medicine and a painkiller increased heart attack risks; and that antidepressants increased suicidal thoughts and behavior in children and teenagers."